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. 2006 Nov 21;4(12):e410. doi: 10.1371/journal.pbio.0040410

Figure 2. Cir1 Directly Regulates Genes Required for Iron Transport.

Figure 2

(A) Cluster analysis of genes required for iron transport show two patterns of differential expression in the cir1 mutant (serotype D), resulting in two main clusters (I and II). Columns represent the log-transformed ratio of the array data from the wild-type strain in low- versus high-iron medium (WT LIM vs. LIM + Fe), the cir1 mutant versus the wild-type strain in low-iron medium (MT vs. WT LIM), the cir1 mutant versus the wild-type strain in high-iron medium (MT vs. WT LIM + Fe), and the cir1 mutant in low- versus high-iron medium (MT LIM vs. LIM + Fe).

(B) RNA blot analysis to confirm differential expression of genes required for iron transport in both the serotype D and the serotype A strains grown in a low-iron medium (L) or high-iron medium (H). WT, wild type.