Figure 6. Cir1 Is a Central Regulator of the Iron Regulon, Virulence Factor Expression, and Virulence-Associated Signaling Pathways.

A schematic of the functions controlled by Cir1 is shown to indicate positive and negative regulation, and interconnections between signalling pathways and downstream target functions. Red arrows indicate positive regulation by Cir1, and blue blunt arrows indicate negative regulation by Cir1. The genes beneath each functional box are downstream targets of Cir1 as experimentally determined by the present study and as listed in Table 3. Gene names are listed for those that have already been characterized; TIGR gene identifiers are used for the other genes.