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. 1978 Oct;26:193–206. doi: 10.1289/ehp.7826193

Effects of anesthesia on cardiovascular control mechanisms.

S F Vatner
PMCID: PMC1637240  PMID: 363416

Abstract

The manner in which general anesthesia affects circulatory control was studied by examining the effects of commonly employed anesthetics on left ventricular function and distribution of cardiac output, and the extent to which responses to physiological and pharmacological stimuli are modified by general anesthesia. While commonly employed anesthetics affect almost every aspect of the circulatory system, the importance of general anesthesia on the circulation tends to be underestimated by considering only its direct effects. More important is the modification of the organism's integrative response to any perturbation. Major differences often directionally opposite, in responses of conscious and anesthetized animals were found for reflex control of the circulation, effects of hemorrhage and alterations in preload and after load. In addition, commonly employed pharmacologic agents, e.g., cardiac glycosdies, catecholamines, and morphine sulfate exerted differing actions in the conscious and anesthetized states. Thus, while it is generally held that the overall responses to complex physiological functions such as exercise or eating can be best described in the intact, conscious organism, the importance of conducting any experiment involving integrative control of the circulation in the conscious organism should also be recognized.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABEL F. L., MURPHY Q. R. Mesenteric, renal, and iliac vascular resistance in dogs after hemorrhage. Am J Physiol. 1962 May;202:978–980. doi: 10.1152/ajplegacy.1962.202.5.978. [DOI] [PubMed] [Google Scholar]
  2. BERNE R. M. Effect of epinephrine and norepinephrine on coronary circulation. Circ Res. 1958 Sep;6(5):644–655. doi: 10.1161/01.res.6.5.644. [DOI] [PubMed] [Google Scholar]
  3. BLINKS J. R., KOCH-WESER J. Analysis of the effects of changes in rate and rhythm upon myocardial contractility. J Pharmacol Exp Ther. 1961 Dec;134:373–389. [PubMed] [Google Scholar]
  4. Berkowitz W. D., Scherlag B. J., Stein E., Damato A. N. Relative roles of sympathetic and parasympathetic nervous systems in the carotid sinus reflex in dogs. Circ Res. 1969 Mar;24(3):447–455. doi: 10.1161/01.res.24.3.447. [DOI] [PubMed] [Google Scholar]
  5. Boerth R. C., Covell J. W., Pool P. E., Ross J., Jr Increased myocardial oxygen consumption and contractile state associated with increased heart rate in dogs. Circ Res. 1969 May;24(5):725–734. doi: 10.1161/01.res.24.5.725. [DOI] [PubMed] [Google Scholar]
  6. Boettcher D. H., Vatner S. F., Heyndrickx G. R., Braunwald E. Extent of utilization of the Frank-Starling mechanism in conscious dogs. Am J Physiol. 1978 Apr;234(4):H338–H345. doi: 10.1152/ajpheart.1978.234.4.H338. [DOI] [PubMed] [Google Scholar]
  7. Brooks H. L., Stein P. D., Matson J. L., Hyland J. W. Dopamine-induced alterations in coronary hemodynamics in dogs. Circ Res. 1969 May;24(5):699–704. doi: 10.1161/01.res.24.5.699. [DOI] [PubMed] [Google Scholar]
  8. COTTEN M. D., STOPP P. E. Action of digitalis on the nonfailing heart of the dog. Am J Physiol. 1958 Jan;192(1):114–120. doi: 10.1152/ajplegacy.1957.192.1.114. [DOI] [PubMed] [Google Scholar]
  9. Chien S. Role of the sympathetic nervous system in hemorrhage. Physiol Rev. 1967 Apr;47(2):214–288. doi: 10.1152/physrev.1967.47.2.214. [DOI] [PubMed] [Google Scholar]
  10. Eckberg D. L., Drabinsky M., Braunwald E. Defective cardiac parasympathetic control in patients with heart disease. N Engl J Med. 1971 Oct 14;285(16):877–883. doi: 10.1056/NEJM197110142851602. [DOI] [PubMed] [Google Scholar]
  11. GREGG D. E., SABISTON D. C., THEILEN E. O. Performance of the heart: changes in left ventricular end-diastolic pressure and stroke work during infusion and following exercise. Physiol Rev. 1955 Jan;35(1):130–136. doi: 10.1152/physrev.1955.35.1.130. [DOI] [PubMed] [Google Scholar]
  12. Gaal P. G., Kattus A. A., Kolin A., Ross G. Effects of adrenaline and noradrenaline on coronary blood flow before and after beta-adrenergic blockade. Br J Pharmacol Chemother. 1966 Mar;26(3):713–722. doi: 10.1111/j.1476-5381.1966.tb01851.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gebber G. L., Snyder D. W. Hypothalamic control of baroreceptor reflexes. Am J Physiol. 1970 Jan;218(1):124–131. doi: 10.1152/ajplegacy.1970.218.1.124. [DOI] [PubMed] [Google Scholar]
  14. Glick G. Importance of the carotid sinus baroreceptors in the regulation of myocardial performance. J Clin Invest. 1971 May;50(5):1116–1123. doi: 10.1172/JCI106583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Goldberg L. I. Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev. 1972 Mar;24(1):1–29. [PubMed] [Google Scholar]
  16. Greenway C. V., Lawson A. E. The effect of haemorrhage on venous return and regional blood flow in the anaesthetized cat. J Physiol. 1966 Jun;184(4):856–871. doi: 10.1113/jphysiol.1966.sp007952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. HARDIN R. A., SCOTT J. B., HADDY F. J. Effect of epinephrine and norepinephrine on coronary vascular resistance in dogs. Am J Physiol. 1961 Aug;201:276–280. doi: 10.1152/ajplegacy.1961.201.2.276. [DOI] [PubMed] [Google Scholar]
  18. HOLT J. P. Effects of plethora and hemorrhage on left ventricular volume and pressure. Circ Res. 1957 May;5(3):273–280. doi: 10.1161/01.res.5.3.273. [DOI] [PubMed] [Google Scholar]
  19. Hackett J. G., Abboud F. M., Mark A. L., Schmid P. G., Heistad D. D. Coronary vascular responses to stimulation of chemoreceptors and baroreceptors: evidence for reflex activation of vagal cholinergic innervation. Circ Res. 1972 Jul;31(1):8–17. doi: 10.1161/01.res.31.1.8. [DOI] [PubMed] [Google Scholar]
  20. Haddy F. J., Overbeck H. W., Daugherty R. M., Jr Peripheral vascular resistance. Annu Rev Med. 1968;19:167–194. doi: 10.1146/annurev.me.19.020168.001123. [DOI] [PubMed] [Google Scholar]
  21. Higgins C. B., Vatner S. F., Braunwald E. Regional hemodynamic effects of a digitalis glycoside in the conscious dog with and without experimental heart failure. Circ Res. 1972 Apr;30(4):406–417. doi: 10.1161/01.res.30.4.406. [DOI] [PubMed] [Google Scholar]
  22. Higgins C. B., Vatner S. F., Franklin D., Braunwald E. Extent of regulation of the heart's contractile state in the conscious dog by alteration in the frequency of contraction. J Clin Invest. 1973 May;52(5):1187–1194. doi: 10.1172/JCI107285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Hockman C. H., Talesnik J., Livingston K. E. Central nervous system modulation of baroceptor reflexes. Am J Physiol. 1969 Dec;217(6):1681–1689. doi: 10.1152/ajplegacy.1969.217.6.1681. [DOI] [PubMed] [Google Scholar]
  24. Korner P. I. Integrative neural cardiovascular control. Physiol Rev. 1971 Apr;51(2):312–367. doi: 10.1152/physrev.1971.51.2.312. [DOI] [PubMed] [Google Scholar]
  25. MCGIFF J. C. THE RENAL VASCULAR RESPONSE TO HEMORRHAGE. J Pharmacol Exp Ther. 1964 Aug;145:181–186. [PubMed] [Google Scholar]
  26. Manders W. T., Vatner S. F. Effects of sodium pentobarbital anesthesia on left ventricular function and distribution of cardiac output in dogs, with particular reference to the mechanism for tachycardia. Circ Res. 1976 Oct;39(4):512–517. doi: 10.1161/01.res.39.4.512. [DOI] [PubMed] [Google Scholar]
  27. Monroe R. G., Gamble W. J., LaFarge C. G., Kumar A. E., Stark J., Sanders G. L., Phornphutkul C., Davis M. The Anrep effect reconsidered. J Clin Invest. 1972 Oct;51(10):2573–2583. doi: 10.1172/JCI107074. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. RUSHMER R. F., SMITH O., FRANKLIN D. Mechanisms of cardiac control in exercise. Circ Res. 1959 Jul;7(4):602–627. doi: 10.1161/01.res.7.4.602. [DOI] [PubMed] [Google Scholar]
  29. SARNOFF S. J., BERGLUND E. Ventricular function. I. Starling's law of the heart studied by means of simultaneous right and left ventricular function curves in the dog. Circulation. 1954 May;9(5):706–718. doi: 10.1161/01.cir.9.5.706. [DOI] [PubMed] [Google Scholar]
  30. SARNOFF S. J., GILMORE J. P., BROCKMAN S. K., MITCHELL J. H., LINDEN R. J. Regulation of ventricular contraction by the carotid sinus. Its effect on atrial and ventricular dynamics. Circ Res. 1960 Sep;8:1123–1136. doi: 10.1161/01.res.8.5.1123. [DOI] [PubMed] [Google Scholar]
  31. SARNOFF S. J., GILMORE J. P., WALLACE A. G., SKINNER N. S., Jr, MITCHELL J. H., DAGGETT W. M. EFFECT OF ACETYL STROPHANTHIDIN THERAPY ON CARDIAC DYNAMICS, OXYGEN CONSUMPTION AND EFFICIENCY IN THE ISOLATED HEART WITH AND WITHOUT HYPOXIA. Am J Med. 1964 Jul;37:3–13. doi: 10.1016/0002-9343(64)90207-4. [DOI] [PubMed] [Google Scholar]
  32. SARNOFF S. J., MITCHELL J. H., GILMORE J. P., REMENSNYDER J. P. Homeometric autoregulation in the heart. Circ Res. 1960 Sep;8:1077–1091. doi: 10.1161/01.res.8.5.1077. [DOI] [PubMed] [Google Scholar]
  33. SARNOFF S. J., MITCHELL J. H. The regulation of the performance of the heart. Am J Med. 1961 May;30:747–771. doi: 10.1016/0002-9343(61)90211-x. [DOI] [PubMed] [Google Scholar]
  34. Shanbour L. L., Jacobson E. D., Brobmann G. F., Hinshaw L. B. Effects of ouabain on splanchnic hemodynamics in the rhesus monkey. Am Heart J. 1971 Apr;81(4):511–515. doi: 10.1016/0002-8703(71)90367-x. [DOI] [PubMed] [Google Scholar]
  35. Vatner S. F., Boettcher D. H. Regulation of cardiac output by stroke volume and heart rate in conscious dogs. Circ Res. 1978 Apr;42(4):557–561. doi: 10.1161/01.res.42.4.557. [DOI] [PubMed] [Google Scholar]
  36. Vatner S. F., Braunwald E. Effects of chronic heart failure on the inotropic response of the right ventricle of the conscious dog to a cardiac glycoside and to tachycardia. Circulation. 1974 Oct;50(4):728–734. doi: 10.1161/01.cir.50.4.728. [DOI] [PubMed] [Google Scholar]
  37. Vatner S. F. Effects of hemorrhage on regional blood flow distribution in dogs and primates. J Clin Invest. 1974 Aug;54(2):225–235. doi: 10.1172/JCI107757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Vatner S. F., Franklin D., Braunwald E. Effects of anesthesia and sleep on circulatory response to carotid sinus nerve stimulation. Am J Physiol. 1971 May;220(5):1249–1255. doi: 10.1152/ajplegacy.1971.220.5.1249. [DOI] [PubMed] [Google Scholar]
  39. Vatner S. F., Franklin D., Van Citters R. L., Braunwald E. Effects of carotid sinus nerve stimulation on the coronary circulation of the conscious dog. Circ Res. 1970 Jul;27(1):11–21. doi: 10.1161/01.res.27.1.11. [DOI] [PubMed] [Google Scholar]
  40. Vatner S. F., Higgins C. B., Braunwald E. Effects of norepinephrine on coronary circulation and left ventricular dynamics in the conscious dog. Circ Res. 1974 Jun;34(6):812–823. doi: 10.1161/01.res.34.6.812. [DOI] [PubMed] [Google Scholar]
  41. Vatner S. F., Higgins C. B., Franklin D., Braunwald E. Effects of a digitalis glycoside on coronary and systemic dynamics in conscious dogs. Circ Res. 1971 Apr;28(4):470–479. doi: 10.1161/01.res.28.4.470. [DOI] [PubMed] [Google Scholar]
  42. Vatner S. F., Higgins C. B., Franklin D., Braunwald E. Extent of carotid sinus regulation of the myocardial contractile state in conscious dogs. J Clin Invest. 1972 Apr;51(4):995–1008. doi: 10.1172/JCI106893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Vatner S. F., Higgins C. B., Patrick T., Franklin D., Braunwald E. Effects of cardiac depression and of anesthesia on the myocardial action of a cardiac glycoside. J Clin Invest. 1971 Dec;50(12):2585–2595. doi: 10.1172/JCI106759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Vatner S. F., Marsh J. D., Swain J. A. Effects of morphine on coronary and left ventricular dynamics in conscious dogs. J Clin Invest. 1975 Feb;55(2):207–217. doi: 10.1172/JCI107923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Vatner S. F., McRitchie R. J. Interaction of the chemoreflex and the pulmonary inflation reflex in the regulation of coronary circulation in conscious dogs. Circ Res. 1975 Nov;37(5):664–673. doi: 10.1161/01.res.37.5.664. [DOI] [PubMed] [Google Scholar]
  46. Vatner S. F., Millard R. W., Higgins C. B. Coronary and myocardial effects of dopamine in the conscious dog: parasympatholytic augmentation of pressor and inotropic actions. J Pharmacol Exp Ther. 1973 Nov;187(2):280–295. [PubMed] [Google Scholar]
  47. Vatner S. F., Monroe R. G., McRitchie R. J. Effects of anesthesia, tachycardia, and autonomic blockade on the Anrep effect in intact dogs. Am J Physiol. 1974 Jun;226(6):1450–1456. doi: 10.1152/ajplegacy.1974.226.6.1450. [DOI] [PubMed] [Google Scholar]
  48. Vatner S. F., Smith N. T. Effects of halothane on left ventricular function and distribution of regional blood flow in dogs and primates. Circ Res. 1974 Feb;34(2):155–167. doi: 10.1161/01.res.34.2.155. [DOI] [PubMed] [Google Scholar]
  49. WALTON R. P., LEARY J. S., JONES H. P. Comparative increase in ventricular contractile force produced by several cardiac glycosides. J Pharmacol Exp Ther. 1950 Apr;98(41):346–357. [PubMed] [Google Scholar]
  50. WARBASSE J. R., BRAUNWALD E., AYGEN M. M. Starling's law of the heart. VII. Ventricular function in closed-chest unanesthetized dogs. Am J Physiol. 1963 Mar;204:439–445. doi: 10.1152/ajplegacy.1963.204.3.439. [DOI] [PubMed] [Google Scholar]
  51. Weiss G. K., Crill W. E. Carotid sinus nerve: primary afferent depolarization evoked by hypothalamic stimulation. Brain Res. 1969 Nov;16(1):269–272. doi: 10.1016/0006-8993(69)90100-0. [DOI] [PubMed] [Google Scholar]

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