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. 1997 Feb;41(2):475–477. doi: 10.1128/aac.41.2.475

Comparative evaluation of the inhibitory activities of the novel penicillanic acid sulfone Ro 48-1220 against beta-lactamases that belong to groups 1, 2b, and 2be.

L S Tzouvelekis 1, M Gazouli 1, E E Prinarakis 1, E Tzelepi 1, N J Legakis 1
PMCID: PMC163734  PMID: 9021212

Abstract

The inhibitory activity of the penicillanic acid sulfone Ro 48-1220 against group 1, 2b, and 2be beta-lactamases was evaluated. Ro 48-1220 inhibited TEM and SHV as effectively as clavulanate and tazobactam. It also inhibited group 1 beta-lactamases at lower concentrations than tazobactam. Ro 48-1220, at a concentration of 4 micrograms/ml, protected ceftriaxone and ceftazidime against strains producing group 1 and 2be beta-lactamases.

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Selected References

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