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. 1979 Apr;29:95–104. doi: 10.1289/ehp.792995

Nutritional influences on metal toxicity: cadmium as a model toxic element.

M R Fox
PMCID: PMC1637380  PMID: 510248

Abstract

The nutrient quality of the diet has been shown repeatedly to be a significant factor in modifying the response of man and animals to toxic element exposure. Deficiencies of several essential nutrients have been shown to exacerbate the effects of cadmium and supplements of such nutrients have been shown to ameliorate the toxicity. Thus the effects of exposure to a toxic element, such as cadmium, may vary, depending on interactions with other elements which are present in the diet in different concentrations.

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Selected References

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  1. Banis R. J., Pond W. G., Walker E. F., Jr, O'Connor J. R. Dietary cadmium, iron, and zinc interactions in the growing rat. Proc Soc Exp Biol Med. 1969 Mar;130(3):802–806. doi: 10.3181/00379727-130-33659. [DOI] [PubMed] [Google Scholar]
  2. Bunn C. R., Matrone G. In vivo interactions of cadmium, copper, zinc and iron in the mouse and rat. J Nutr. 1966 Dec;90(4):395–399. doi: 10.1093/jn/90.4.395. [DOI] [PubMed] [Google Scholar]
  3. Factors influencing metabolism and toxicity of metals: a consensus report. Environ Health Perspect. 1978 Aug;25:3–41. doi: 10.1289/ehp.25-1637186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Flanagan P. R., McLellan J. S., Haist J., Cherian G., Chamberlain M. J., Valberg L. S. Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology. 1978 May;74(5 Pt 1):841–846. [PubMed] [Google Scholar]
  5. Fleischer M., Sarofim A. F., Fassett D. W., Hammond P., Shacklette H. T., Nisbet I. C., Epstein S. Environmental impact of cadmium: a review by the Panel on Hazardous Trace Substances. Environ Health Perspect. 1974 May;7:253–323. doi: 10.1289/ehp.747253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fowler B. A., Jones H. S., Brown H. W., Haseman J. K. The morphological effects of chronic cadmium administration on the renal vasculature of rats given low and normal calcium diets. Toxicol Appl Pharmacol. 1975 Nov;34(2):233–252. doi: 10.1016/0041-008x(75)90028-9. [DOI] [PubMed] [Google Scholar]
  7. Fox M. R., Fry B. E., Jr Cadmium toxicity decreased by dietary ascorbic acid supplements. Science. 1970 Sep 4;169(3949):989–991. doi: 10.1126/science.169.3949.989. [DOI] [PubMed] [Google Scholar]
  8. Fox M. R., Fry B. E., Jr, Harland B. F., Schertel M. E., Weeks C. E. Effect of ascorbic acid on cadmium toxicity in the young coturnix. J Nutr. 1971 Oct;101(10):1295–1305. doi: 10.1093/jn/101.10.1295. [DOI] [PubMed] [Google Scholar]
  9. Fox M. R. Nutritional considerations in designing animal models of metal toxicity in man. Environ Health Perspect. 1978 Aug;25:137–140. doi: 10.1289/ehp.7825137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Guthrie B. E., Robinson M. F. Daily intakes of manganese, copper, zinc and cadmium by New Zealand women. Br J Nutr. 1977 Jul;38(1):55–63. doi: 10.1079/bjn19770061. [DOI] [PubMed] [Google Scholar]
  11. HILL C. H., MATRONE G., PAYNE W. L., BARBER C. W. In vivo interactions of cadmium with copper, zinc and iron. J Nutr. 1963 Jul;80:227–235. doi: 10.1093/jn/80.3.227. [DOI] [PubMed] [Google Scholar]
  12. Hambidge K. M., Hambidge C., Jacobs M., Baum J. D. Low levels of zinc in hair, anorexia, poor growth, and hypogeusia in children. Pediatr Res. 1972 Dec;6(12):868–874. doi: 10.1203/00006450-197212000-00003. [DOI] [PubMed] [Google Scholar]
  13. Hambidge K. M., Silverman A. Pica with rapid improvement after dietary zinc supplementation. Arch Dis Child. 1973 Jul;48(7):567–568. doi: 10.1136/adc.48.7.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hambidge K. M., Walravens P. A., Brown R. M., Webster J., White S., Anthony M., Roth M. L. Zinc nutrition of preschool children in the Denver Head Start program. Am J Clin Nutr. 1976 Jul;29(7):734–738. doi: 10.1093/ajcn/29.7.734. [DOI] [PubMed] [Google Scholar]
  15. Hamilton D. L., Smith M. W. Inhibition of intestinal calcium uptake by cadmium and the effect of a low calcium diet on cadmium retention. Environ Res. 1978 Apr;15(2):175–184. doi: 10.1016/0013-9351(78)90094-4. [DOI] [PubMed] [Google Scholar]
  16. Hamilton D. L., Valberg L. S. Relationship between cadmium and iron absorption. Am J Physiol. 1974 Nov;227(5):1033–1037. doi: 10.1152/ajplegacy.1974.227.5.1033. [DOI] [PubMed] [Google Scholar]
  17. Itokawa Y., Abe T., Tabei R., Tanaka S. Renal and skeletal lesions in experimental cadmium poisoning: histological and biochemical approaches. Arch Environ Health. 1974 Mar;28(3):149–154. doi: 10.1080/00039896.1974.10666456. [DOI] [PubMed] [Google Scholar]
  18. Itokawa Y., Abe T., Tanaka S. Bone changes in experimental chronic cadmium poisoning: radiological and biological approaches. Arch Environ Health. 1973 May;26(5):241–244. doi: 10.1080/00039896.1973.10666266. [DOI] [PubMed] [Google Scholar]
  19. Itokawa Y., Nishino K., Takashima M., Nakata T., Kaito H., Okamoto E., Daijo K., Kawamura J. Renal and skeletal lesions in experimental cadmium poisoning of rats. Histology and renal function. Environ Res. 1978 Apr;15(2):206–217. doi: 10.1016/0013-9351(78)90097-x. [DOI] [PubMed] [Google Scholar]
  20. Jacobs R. M., Jones A. O., Fox M. R., Fry B. E., Jr Retention of dietary cadmium and the ameliorative effect of zinc, copper, and manganese in Japanese quail. J Nutr. 1978 Jan;108(1):22–32. doi: 10.1093/jn/108.1.22. [DOI] [PubMed] [Google Scholar]
  21. Jacobs R. M., Jones A. O., Fry B. E., Jr, Fox M. R. Decreased long-term retention of 115mCd in Japanese quail produced by a combined supplement of zinc, copper, and manganese. J Nutr. 1978 Jun;108(6):901–910. doi: 10.1093/jn/108.6.901. [DOI] [PubMed] [Google Scholar]
  22. Kello D., Kostial K. Influence of age and milk diet on cadmium absorption from the gut. Toxicol Appl Pharmacol. 1977 May;40(2):277–282. doi: 10.1016/0041-008x(77)90098-9. [DOI] [PubMed] [Google Scholar]
  23. Kjellström T. A mathematical model for the accumulation of cadmium in human kidney cortex. Nord Hyg Tidskr. 1971;52(2):111–119. [PubMed] [Google Scholar]
  24. Kjellström T., Shiroishi K., Evrin P. E. Urinary beta2-microglobulin excretion among people exposed to cadmium in the general environment: an epidemiological study in cooperation between Japan and Sweden. Environ Res. 1977 Apr;13(2):318–344. doi: 10.1016/0013-9351(77)90107-4. [DOI] [PubMed] [Google Scholar]
  25. Kobayashi J., Nakahara H., Hasegawa T. [Accumulation of cadmium in organs of mice fed on cadmium-polluted rice]. Nihon Eiseigaku Zasshi. 1971 Dec;26(5):401–407. doi: 10.1265/jjh.26.401. [DOI] [PubMed] [Google Scholar]
  26. Larsson S. E., Piscator M. Effect of cadmium on skeletal tissue in normal and calcium-deficient rats. Isr J Med Sci. 1971 Mar;7(3):495–498. [PubMed] [Google Scholar]
  27. Mahaffey K. R., Corneliussen P. E., Jelinek C. F., Fiorino J. A. Heavy metal exposure from foods. Environ Health Perspect. 1975 Dec;12:63–69. doi: 10.1289/ehp.751263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. McLellan J. S., Flanagan P. R., Chamberlain M. J., Valberg L. S. Measurement of dietary cadmium absorption in humans. J Toxicol Environ Health. 1978 Jan;4(1):131–138. doi: 10.1080/15287397809529650. [DOI] [PubMed] [Google Scholar]
  29. Muto Y., Omori M. Nutritional influence of the onset of renal damage due to long-term administration of cadmium in young adult rats. J Nutr Sci Vitaminol (Tokyo) 1977;23(4):349–360. doi: 10.3177/jnsv.23.349. [DOI] [PubMed] [Google Scholar]
  30. Nogawa K., Ishizaki A., Kawano S. Statistical observations of the dose-response relationships of cadmium based on epidemiological studies in the Kakehashi River basin. Environ Res. 1978 Apr;15(2):185–198. doi: 10.1016/0013-9351(78)90095-6. [DOI] [PubMed] [Google Scholar]
  31. Petering H. G., Johnson M. A., Stemmer K. L. Studies of zinc metabolism in the rat. I. Dose-response effects of cadmium. Arch Environ Health. 1971 Aug;23(2):93–101. doi: 10.1080/00039896.1971.10665962. [DOI] [PubMed] [Google Scholar]
  32. Pond W. G., Walker E. F., Jr Effect of dietary Ca and Cd level of pregnant rats on reproduction and on dam and progeny tissue mineral concentrations. Proc Soc Exp Biol Med. 1975 Mar;148(3):665–668. doi: 10.3181/00379727-148-38606. [DOI] [PubMed] [Google Scholar]
  33. Pond W. G., Walker E. F., Jr, Kirtland D. Cadmium-induced anemia in growing pigs: protective effect of oral or parenteral iron. J Anim Sci. 1973 Jun;36(6):1122–1124. doi: 10.2527/jas1973.3661122x. [DOI] [PubMed] [Google Scholar]
  34. Ragan H. A. Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats. J Lab Clin Med. 1977 Oct;90(4):700–706. [PubMed] [Google Scholar]
  35. Richardson M. E., Fox M. R. Dietary cadmium and enteropathy in the Japanese quail: histochemical and ultrastructural studies. Lab Invest. 1974 Dec;31(6):722–731. [PubMed] [Google Scholar]
  36. Richardson M. E., Fox M. R., Fry B. E., Jr Pathological changes produced in Japanese quail by ingestion of cadmium. J Nutr. 1974 Mar;104(3):323–338. doi: 10.1093/jn/104.3.323. [DOI] [PubMed] [Google Scholar]
  37. SCHROEDER H. A., BALASSA J. J. Abnormal trace metals in man: cadmium. J Chronic Dis. 1961 Aug;14:236–258. doi: 10.1016/0021-9681(61)90156-4. [DOI] [PubMed] [Google Scholar]
  38. SUPPLEE W. C. Antagonistic relationship between dietary cadmium and zinc. Science. 1963 Jan 11;139(3550):119–120. doi: 10.1126/science.139.3550.119. [DOI] [PubMed] [Google Scholar]
  39. Sasser L. B., Jarboe G. E. Intestinal absorption and retention of cadmium in neonatal rat. Toxicol Appl Pharmacol. 1977 Aug;41(2):423–431. doi: 10.1016/0041-008x(77)90043-6. [DOI] [PubMed] [Google Scholar]
  40. Schroeder H. A., Nason A. P., Tipton I. H., Balassa J. J. Essential trace metals in man: zinc. Relation to environmental cadmium. J Chronic Dis. 1967 Apr;20(4):179–210. doi: 10.1016/0021-9681(67)90002-1. [DOI] [PubMed] [Google Scholar]
  41. Stowe H. D., Goyer R. A., Medley P., Cates M. Influence of dietary pyridoxine on cadmium toxicity in rats. Arch Environ Health. 1974 Apr;28(4):209–216. doi: 10.1080/00039896.1974.10666470. [DOI] [PubMed] [Google Scholar]
  42. Stowe H. D., Wilson M., Goyer R. A. Clinical and morphologic effects of oral cadmium toxicity in rabbits. Arch Pathol. 1972 Nov;94(5):389–405. [PubMed] [Google Scholar]
  43. Sugawara C., Sugawara N. The effect of cadmium on soluble proteins, enzymes, and essential metals of the duodenal mucosa. Arch Environ Contam Toxicol. 1977;6(1):121–128. doi: 10.1007/BF02097755. [DOI] [PubMed] [Google Scholar]
  44. Valberg L. S., Haist J., Cherian M. G., Delaquerriere-Richardson L., Goyer R. A. Cadmium-induced enteropathy: comparative toxicity of cadmium chloride and cadmium-thionein. J Toxicol Environ Health. 1977 Mar;2(4):963–975. doi: 10.1080/15287397709529495. [DOI] [PubMed] [Google Scholar]
  45. Valberg L. S., Sorbie J., Hamilton D. L. Gastrointestinal metabolism of cadmium in experimental iron deficiency;. Am J Physiol. 1976 Aug;231(2):462–467. doi: 10.1152/ajplegacy.1976.231.2.462. [DOI] [PubMed] [Google Scholar]
  46. Vallee B. L., Ulmer D. D. Biochemical effects of mercury, cadmium, and lead. Annu Rev Biochem. 1972;41(10):91–128. doi: 10.1146/annurev.bi.41.070172.000515. [DOI] [PubMed] [Google Scholar]
  47. Washko P. W., Cousins R. J. Metabolism of 109Cd in rats fed normal and low-calcium diets. J Toxicol Environ Health. 1976 Jul;1(6):1055–1066. doi: 10.1080/15287397609529408. [DOI] [PubMed] [Google Scholar]
  48. Washko P., Cousins R. J. Role of dietary calcium and calcium binding protein in cadmium toxicity in rats. J Nutr. 1977 May;107(5):920–928. doi: 10.1093/jn/107.5.920. [DOI] [PubMed] [Google Scholar]
  49. Webster W. S. Cadmium-induced fetal growth retardation in the mouse. Arch Environ Health. 1978 Jan-Feb;33(1):36–42. doi: 10.1080/00039896.1978.10667306. [DOI] [PubMed] [Google Scholar]
  50. White H. S. Inorganic elements in weighed diets of girls and young women. J Am Diet Assoc. 1969 Jul;55(1):38–43. [PubMed] [Google Scholar]

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