Table 1.
Expression of CYP19(I.1)−2400:hGH and CYP19(I.1)−501:hGH fusion genes in transgenic mice
| Transgene | Sex (F0) | Line | Copy no. | Placenta
|
Nonplacental tissues
|
||
|---|---|---|---|---|---|---|---|
| Generation | Expression | Generation | Expression | ||||
| −2,400 | NA | 8-1 | 3 | F0 | − | ND | ND |
| NA | 9-1 | 2 | F0 | − | ND | ND | |
| NA | 3-4 | 3 | F0 | − | ND | ND | |
| NA | 5-4 | 5 | F0 | + | F0 | − | |
| NA | A4-6 | 12-25 | F0 | + | F0 | − | |
| NA | A7-6 | 6-12 | F0 | + | F0 | − | |
| NA | A8-10 | 12-25 | F0 | − | ND | ND | |
| −501 | Male | 2218 | 12-25 | F1 | + | F1 | Ovary (low) |
| Male | 2219 | 25 | F1 | + | F1 | − | |
| Male | 2222 | 12-25 | F1 | + | F1 | − | |
| Female | 2146 | 1-3 | F1 | + | F0 | Brain (low) | |
| Female | 2152 | 6-12 | F1 | + | F0 | − | |
NA, not applicable; ND, not determined.