Figure 1.

Nucleotide sequence of RANTES promoter region. Numbers indicate nucleotide positions relative to the major transcription start site marked by a triangle. The numbers −403 and −28 indicate the two polymorphic positions. Possible consensus sites for NFκB, NFIL6, CCAAT, and TATA are underlined. Primer positions used for PCR amplification and sequence determination are underlined with arrows, indicating the direction of the primers. SacI and KpnI restriction-enzyme sites used to generate the luciferase plasmid are boxed. Asterisks below the sequence indicate the nucleotides that were not present in a previous report (32). Each of our sequences possesses these additional nucleotides. At present, it is unclear whether or not these differences represent sequence polymorphisms between white and Japanese individuals.