Fig. 1.

Modeling the basic motif c1 (nucleosome core, linker DNA, and histone tails) to yield the final model c2: the atomistic nucleosome core n1 is modeled as a rigid body with a uniformly distributed set of charges (n2); the linker DNA d1 is treated by using the discrete elastic chain model d2; and the histone tails [(t1), H3 tail is shown] are represented by using the subunit model t2 and then coarse-grained further to the protein bead chain t3. The tails in c2 are colored blue (H3), green (H4), yellow (H2A), and red (H2B).