Fig. 1.

Inhibition of PGC-1α expression in various types of muscle atrophy. (a) Rat models of muscle atrophy: acute streptozotocin-induced diabetes mellitus, chronic renal failure induced by subtotal nephrectomy, and cancer cachexia induced by Yoshida ascities hepatoma. Animal models were described in depth elsewhere (22, 36, 37). Samples were taken at times when the muscles were undergoing rapid weight loss. PGC-1α was assayed by quantitative PCR. (b) Denervation by unilateral transection of the sciatic nerve in mouse. Results are expressed relative to mRNA levels in the contralateral enervated muscle.