Table 2.

Cell-cycle profiles of PALA-treated HCT116 cells and p53- and p21-null derivatives

	Percentage of cells in
Hours of treatment	G1	G2/M	S
SKOV3
0	50	24	26
24	48	5	47
48	77	12	11
72	76	12	12
96	87	6	7
p53-null
0	37	19	44
24	40	8	52
48	23	20	57
72	37	19	44
96	45	20	35
p21-null
0	37	21	42
24	24	17	59
48	23	13	64
72	18	11	71
96	21	13	66

Data are shown from a FACS analysis of cells treated with 250 μM PALA for 24–96 h and stained with propidium iodide to measure DNA content.