Table 3.

Effect of voluntary running wheel exercise for 2 weeks on the weight of the parametrial fat pads and UVB-induced apoptotic sunburn cells in the epidermis of p53 knockout mice

Group	Body weight, g per mouse	Weight of fat pads, g per mouse	% Apoptotic sunburn cells
p53−/− mice
No running wheel	30.6 ± 0.98	0.34 ± 0.03	0.15 ± 0.02
Running wheel	31.5 ± 0.66	0.22 ± 0.02*	0.29 ± 0.03*
% change	3	35 ↓	93 ↑
p53+/+ mice
No running wheel	31.1 ± 0.57	0.35 ± 0.02	0.27 ± 0.03
Running wheel	31.1 ± 0.65	0.21 ± 0.02*	0.52 ± 0.06*
% change	0	40 ↓	93 ↑

Male p53 knockout mice and littermate controls (7–8 weeks old, 10 mice per group) were placed in cages with or without a running wheel for 2 weeks. The mice were irradiated once with UVB (30 mJ/cm²) and killed 6 h later. The weight of the parametrial fat pads was determined, and apoptotic sunburn cells were measured morphologically. Each value represents the mean ± SE. ∗, P < 0.01.