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Contrasting phenotypes between Ctla4 knockdown and knockout mice. (A) Cellularity in lymphoid organs of NOD. Ctla4o/o, CT4KD7, and PL4 mice at 3 or 12 wk of age (mean ± SD). MLN, mesenteric; ILN, inguinal. (B) A summary of histology survey. 1, heart; 2, lung; 3, exocrine pancreas; 4, islet; 5, liver; 6, skeletal muscle. (C) Representative hematoxylin and eosin sections of pancreas and heart from 3- to 5-wk-old mice. (Original magnification: ×100.)
