Table 1.
Hematological profile of plt1 mutant mice
| Peripheral blood | Genotype |
|||||
|---|---|---|---|---|---|---|
| +/+,n = 18 | plt1/+,n = 20 | plt1/plt1,n = 15 | rag1−/− +/+,n = 5 | rag1−/−plt1/+,n = 9 | rag1−/−plt1/plt1, n = 5 | |
| Platelets, ×10−6 per ml | 1,265 ± 242 | 1,305 ± 188 | 522 ± 255* | 1,363 ± 253 | 1,394 ± 189 | 461 ± 320‡ |
| Platelet volume, fl | 8.4 ± 0.5 | 8.5 ± 0.3 | 10.0 ± 1.5* | 7.6 ± 0.7 | 7.4 ± 0.5 | 9.2 ± 0.9 |
| Hematocrit, % | 55.4 ± 1.7 | 56.3 ± 1.9 | 55.2 ± 4.2 | 52.7 ± 2.2 | 55.4 ± 2.2 | 54.9 ± 2.6 |
| White blood cells, ×10−3 per ml | 9.0 ± 1.5 | 9.4 ± 1.9 | 11.1 ± 2.3 | 1.8 ± 0.5† | 1.5 ± 0.4† | 1.2 ± 0.9† |
| Neutrophils | 0.9 ± 0.2 | 0.8 ± 0.2 | 0.8 ± 0.3 | 0.6 ± 0.3 | 0.6 ± 0.2 | 0.4 ± 0.5 |
| Lymphocytes | 7.7 ± 1.5 | 8.1 ± 1.7 | 9.6 ± 2.1 | 0.8 ± 0.1† | 0.7 ± 0.3† | 0.5 ± 0.3† |
| Monocytes | 0.05 ± 0.03 | 0.05 ± 0.03 | 0.04 ± 0.02 | 0.05 ± 0.02 | 0.04 ± 0.02 | 0.02 ± 0.02 |
| Eosinophils | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.1 ± 0.03 | 0.1 ± 0.1 |
Means ± standard deviations are shown. P < 0.05 for comparison of plt1/plt1 with +/+ mice (∗), rag−/− data with that of rag+/+ mice of a given plt1 genotype (†), and rag1−/− plt1/plt1 with rag1−/− +/+mice (‡) (Student's t test with P values adjusted for multiple testing).