Fig. 5.

Fisetin enhances long-term memory in mice, and the effect of different oral doses of fisetin on object recognition over a 10-min test period is shown. Rolipram, injected i.p. at 0.1 mg/kg, served as a positive control. Data represent the mean ± SEM of 10 mice per treatment group. Data were analyzed by one-way ANOVA followed by post hoc comparisons with Fisher's test. ∗, significant difference from vehicle control (P < 0.02). Vehicle, 51.072 ± 4.293; fisetin 5 mg/kg, 60.820 ± 4.521; fisetin 10 mg/kg, 63.628 ± 4.332; fisetin 25 mg/kg, 66.461 ± 2.984; rolipram, 74.132 ± 2.041. Similar results were obtained in two independent, blinded experiments done by PsychoGenics.