Table 1.

In vitro sensitivity to MS-27-275 of human tumor cell lines

Cell line	IC50, μM			p53 gene status*
	MS-27-275	Compound 2	5-FU
A2780	0.0415	0.621	13.7	wt
Calu-3	0.195	>100	41.3	-
HL-60	0.212	42.1	7.09	mu
K562	0.589	58.0	140	mu
St-4	0.820	>100	1.63	-
HT-29	1.29	>100	153	mu
KB-3-1	1.46	>100	51.8	-
Capan-1	1.70	>100	14.2	mu
4-1St	1.92	>100	144	-
HCT-15	4.71	>100	26.3	mu

The procedure to assess IC₅₀ is described in Materials and Methods. 

^*Citation from refs. 42–45. mu, mutant in p53 gene; wt, wild-type in p53 gene; -, the p53 gene status has not been reported.