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Structures and relationships among the prostaglandins. PGE2 and PGD2, major prostaglandin products of activated microglia, are produced enzymatically from arachidonic acid by the action of cyclooxygenase-2 and corresponding synthases, whereas cyclopentenone prostaglandins PGA2, 15d-PGA2, PGJ2, and 15d-PGJ2 are the products of nonenzymatic conversion of the precursor prostaglandins.
