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. 1999 Apr 13;96(8):4668–4673. doi: 10.1073/pnas.96.8.4668

Figure 5.

Figure 5

15d-PGJ2 inhibits iNOS and 3xRel reporter activity. (A) Cells were transfected with murine wild-type (WT) iNOS-luc plasmid or iNOS/mutNFκB-luc plasmid, pretreated with 1 μM 15d-PGJ2 (15d) or vehicle, and stimulated with 80 ng/ml of LPS for 9 h. Results are the mean ± SEM of n = 7 (WT) and n = 5 (iNOS/mutNFκB) independent experiments, each done in triplicate. (B) Cells were transfected with 3xRel-luc plasmid, pretreated with the indicated concentrations of 15d-PGJ2 or vehicle, and stimulated with 80 ng/ml of LPS for 7 h. Results are mean ± SEM of n = 6 independent experiments. Control values in A and B are normalized to 1.0. Asterisk indicates significantly different from LPS-treated samples (P < 0.05).