FIG. 3.

Oral feeding with SIgA7D9 does not reduce viral shedding. (A) Time frame summarizing the kinetics of i.p. and oral passive administration of the various molecular forms of pIgA7D9 and SIgA7D9. (B) Mean percentages of reduction of virus shedding (± standard error) compared to the PBS group are reported from BALB/c mice inoculated i.p. with pIgA7D9 MAb or dosed orally with SIgA7D9, pIgA7D9 MAb, and SC. A statistically significant difference was only achieved for viral shedding in the group receiving pIgA7D9 MAb i.p. (Student's t test, P < 0.005). Similar results were obtained in two other independent experiments. (C) Level of IgA7D9 MAb in mouse feces measured 2 h after passive administration of pIgA7D9 MAb i.p. or SIgA7D9 MAb orally. BD, below the level of detection.