TABLE 2.
Phenotypes of donor PBMC and proviral loads of cells recovered from infected hu-PBMC-NOG micea
| Donor | Surface markers of donor PBMC (%)b
|
Proviral load (%)c
|
||||
|---|---|---|---|---|---|---|
| CD3 | CD4 | CD8 | CD19 | Lavage specimen | Spleen | |
| D | 69.7 | 61.8 | 18.7 | 12.2 | 3.7 | 0.6 |
| 34.0 | 1.4 | |||||
| 2.8 | 0.5 | |||||
| E | 84.7 | 53.4 | 33.9 | 3.0 | 0.6 | 0.1 |
| 12.6 | 1.0 | |||||
| 11.6 | 0.8 | |||||
| F | 67.0 | 48.0 | 31.9 | 2.8 | 0.2 | 0.0 |
| 2.7 | 0.2 | |||||
| 0.6 | 0.1 | |||||
| G | 74.9 | 43.9 | 37.7 | 1.3 | 7.4 | 0.2 |
| 2.8 | 0.6 | |||||
| H | 80.0 | 62.8 | 18.0 | 1.2 | 2.4 | 0.2 |
| 0.4 | 0.0 | |||||
| I | ND | ND | ND | ND | 20.5 | 2.5 |
| 0.1 | 0.3 | |||||
PBMC from the indicated donors were transferred into NOG mice, and these were sacrificed 2 weeks after inoculation of 104 MMC-treated MT-2 cells.
The percentage of cells positive for the specified markers before transfer into mice is shown for each donor.
The proviral loads of human cells recovered from peritoneal lavage and spleens of the different mice are shown as percentages, calculated as described in Materials and Methods. ND, not determined.