TABLE 6.

Proviral load after treatment with tenofovir or AZT beginning one week after infection^a

Condition or treatment	Mouse	Proviral load (%)
		Lavage specimen	Spleen
Untreated	U11	7.4	1.7
	U12	0.1	0.0
	U13	15.4	1.9
	U14	3.8	0.7
Tenofovir	T11	0.0	0.0
	T12	0.2	0.0
	T13	15.9	1.8
	T14	14.5	2.6
Untreated	U21	0.6	0.1
	U22	ND	3.0
	U23	12.6	1.0
	U24	11.6	0.8
AZT	A21	0.0	0.0
	A22	ND	0.6
	A23	2.5	0.0
	A24	0.1	0.0

^aAfter human PBMC transfer and MT-2 inoculation (10³ cells/mouse for the tenofovir group, and 10⁴ cells/mouse for the AZT group), mice were left for one week before starting treatment with tenofovir or AZT. The control groups were injected with PBS instead of the drugs. Mice were sacrificed 7 or 12 days after treatment with AZT or tenofovir, respectively. Splenocytes, as well as cells from the abdominal cavity, were recovered for analysis as described in Materials and Methods. ND, not determined.