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. 2006 Sep 13;80(22):11343–11354. doi: 10.1128/JVI.02072-05

FIG. 1.

FIG. 1.

Genomic organization of HCV and of its subgenomic replicon. (A) Genomic structure of full-length HCV RNA. The single-stranded RNA genome of HCV is divided into the 5′ NTR (single line), the polyprotein coding region (boxed), and the 3′ NTR (single line). The polyprotein coding region is divided into structural and nonstructural regions. The NS5B domain, shown enlarged, contains three functional motifs: the catalytic domain (open box), the regulatory motif (gray box), and the membrane anchor (hatched box). (B) Genomic structure of HCV subgenomic replicon RNA. The single-stranded RNA genome of the subgenomic replicon (30) contains the HCV 5′ NTR (single line), the first 16 codons encoding the HCV core protein (ΔC, gray box), the neomycin phosphotransferase gene (NEO; open box), the EMCV IRES (single line), the nonstructural protein coding regions of HCV from NS3 through NS5B (open box), and the 3′ NTR (single line).