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. 2006 Aug 30;80(22):11381–11384. doi: 10.1128/JVI.01328-06

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Copyright © 2006, American Society for Microbiology

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FIG. 3. — Papillomas induced by quasivirions at 12 weeks postinfection. (A) Papillomas on the dorsal skin of a New Zealand White rabbit inoculated with various dilutions, constructs, and preparations of quasivirus. This rabbit was never exposed to native CRPV virions. (B) Hematoxylin- and eosin-stained tissue section of a papilloma induced by quasivirions composed of CRPV capsid proteins and CRPV_ori genomes. (C) Hematoxylin- and eosin-stained tissue section of a papilloma induced by quasivirions composed of HPV-16 capsid proteins and CRPV_wt genomes. (D) Expression of CRPV L1 (arrows) in a papilloma induced by chimeric HPV-16/CRPV_wt quasivirions is seen following immunohistochemical staining with the MAb CRPV.G4.B. Scale bar, 50 μm.