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. 2006 Sep 6;80(22):11019–11030. doi: 10.1128/JVI.01382-06

FIG. 3.

FIG. 3.

Infection with NL4-R3A increases the frequency of thymocytes expressing active caspase-3. (A) 7AAD-negative live cells were stained for p24 and active caspase-3. Shown is a representative of seven independent experiments from 9 and 12 dpi for mock-, NL4-R3A-, and NL4-R3B-infected thymus. (B) NL4-R3A increases the frequency of total thymocytes with active caspase-3 expression (*, P < 0.05 for NL4-R3A trend line relative to mock and NL4-R3B.) (C) The increase in active caspase-3+ cells in NL4-R3A-infected HF-TOC occurs in both uninfected (p24−) and infected (p24+) thymocytes in proportion to the level of NL4-R3A replication. (*, P < 0.05 for the strength of significance for each trend line.) (B and C) Data are from seven independent experiments.