FIG. 5.

Prevention of thymocyte depletion in T20- and C34-treated HF-TOC in spite of sustained replication. (A to C) NL4-R3A-infected HF-TOC was treated with C34, T20, or saquinavir from 7 dpi for 6 days. Arrows indicate the day of drug addition. (A) Viral load was quantitated by ELISA detection of Gag antigen in the HF-TOC supernatant on the indicated days. Error bars are derived from triplicate samples. (*, P < 0.05 by the student's t test for drug treatment relative to no drug.) (B and C) Similar percentages of CD4⁺ thymocyte protection after T20, C34, and saquinavir treatment were detected 6 days after drug treatment by CD4 and CD8 staining. Error bars are derived from triplicate samples. Shown is a representative of three independent experiments. (*, P < 0.05 by the student's t test relative to no drug.)