TABLE 6.
Effects of inflammation and inflammatory mediators on lipid metabolism
| Lipid undergoing metabolism | Effect ofa:
|
Reference(s) | |||||
|---|---|---|---|---|---|---|---|
| LPS | LTA | TNF-α | IL-1 | IFN-γ | GM-CSF | ||
| Serum or plasma | |||||||
| TG | ↑§ | ↑ | ↑ | ↑ | 19, 121, 124, 276, 391, 392, 497 | ||
| TC | ↓↑ | ↑ | ↔ | 121, 122, 124 | |||
| LCAT | ↓ | 19 | |||||
| PLTP | ↓ | 245 | |||||
| CETP | ↓ | ↓ | ↓ | 190 | |||
| Tissue | |||||||
| LPL | ↓ | ↓ | 256, 257, 392 | ||||
| Liver | |||||||
| HL | ↓ | ↔ | ↓ | 123 | |||
| LDL receptor | ↓ | 314 | |||||
| Monocytes/macrophages | |||||||
| LRP receptor | ↓ | ↓ | 288 | ||||
| ApoE | |||||||
| Serum ApoE | ↑ | 19, 314, 555a | |||||
| Liver ApoE | ↓ | 122, 532b | |||||
| Macrophage ApoE | ↓ | (↓) | ↓ | 360, 586, 620 | |||
a
↑, increase; ↓, decrease; ↔, no change; ↓↑, increased as well as decreased levels were observed.
b
E. S. van Amersfoort et al., unpublished results.