TABLE 7.

Randomized controlled trials of immunotherapy in sepsis and septic shock^a

Type of trial	No. of trials	Total no. of patients	Mortality (%) in patients receiving:
			Placebo	Therapy
Anti-endotoxin	4	2,010	35	35
Anti-IL-1R	3	1,898	35	31
Anti-bradykinin	2	755	36	39
Anti-PAF	2	870	50	45
Anti-TNF	8	4,132	41	40
Soluble TNF-R	2	688	38	40
NSAIDS	3	514	40	37
Steroids	9	1,267	35	39
Activated protein C	1	1,690	31	25
All studies	33	13,824	38	37

^aAdapted from reference 17.