TABLE 1.

EPEC virulence genes

Gene	Alternative or previous name	Function	Reference(s)
bfpA		BFP biogenesis, major pilus subunit—bundlin	40
bfpB		BFP biogenesis, outer membrane	140, 155
bfpC		BFP biogenesis, inner membrane	140
bfpD		BFP biogenesis	162, 168
bfpE		BFP biogenesis, inner membrane scaffold and transporter	15, 140
bfpF		Required for dissociation of BFP bundles	7, 14
bfpG		BFP biogenesis, outer membrane	140
bfpH		Function unknown	162, 168
bfpI		BFP biogenesis, inner membrane	140
bfpJ		BFP biogenesis, inner membrane	140
bfpK		BFP biogenesis, inner membrane	140
bfpL		BFP biogenesis, inner membrane	140
bfpU		BFP biogenesis, periplasmic	140, 156
bfpP		BFP biogenesis, prepilin peptidase	193
bfpT	perA	Regulator of bfp and ler	72, 162, 177
bftV	perB	Accessory factor for PerA	72, 177
bfpW	perC	Accessory factor for PerA	72, 177
escC	sepC	TTSS biogenesis	49
escD	sepE	TTSS biogenesis	49
escF	orf28	TTSS biogenesis, needle component	158, 188
escJ	sepD	TTSS biogenesis	49
escN	sepB	TTSS biogenesis	49
escR	sepI	TTSS biogenesis	49
escS	sepH	TTSS biogenesis	49
escT	sepG	TTSS biogenesis	49
escU	sepF	TTSS biogenesis	49
escV	sepA	TTSS biogenesis	49
sepQ		TTSS biogenesis	49
sepZ		TTSS biogenesis	49
eae	eaeA	Adhesin binds Tir—intimin	90
tir		Translocated intimin receptor; initiates actin pedestal formation	103
espA		Forms filaments between bacteria and host; delivery of effector molecules	57, 107
espB	eaeB	Translocation pore; host cytosolic effector(?)	57, 88, 174
espD		Translocation pore	57, 88
espF	orf30	Disrupts tight-junction integrity; induces cell death	31, 121
espG	rorf2	Effector molecule (function unknown)	46
map	orf19	Damages mitochondria membrane integrity; induces filopodia formation	94, 99, 102
ler	orf1	Regulator for LEE genes and espC	48
cesD	sepE	Chaperone for EspB and EspD	184
cesT	orf21	Chaperone for Tir	36
cesF	rorf10	Chaperone for EspF	47