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Selected strategies to target leukocyte influx
| Phase of leukocyte influx | Target | Agent class |
|---|---|---|
| Leukocyte attraction (chemotaxis) | Chemokines, e.g., IL-8, MCP-1 | Monoclonal antibodies |
| Leukocyte activation | cAMP production up | A2A adenosine receptor agonist |
| cAMP degradation down | Phosphodiesterase inhibitors, e.g., pentoxifylline | |
| Leukocyte adhesion and migration | Selectin class of adhesins | Carbohydrate antagonist, e.g., fucoidin |
| Integrin class of adhesins | Monoclonal antibodies, peptides |
