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Strategies to enhance repair
| Cellular target | Aim | Potential agents |
|---|---|---|
| Endothelium | Restore blood-brain barrier | Endothelial growth factors, e.g., angiopoietin |
| Limit vasogenic edema | ||
| Protect composition of CSF and interstitial fluid in brain | ||
| Neurons | Stimulate recovery | Growth factors, e.g., transforming growth factor beta, VEGF |
| Prevent neuron loss | ||
| Replace dead neurons | Growth factors, e.g., epidermal growth factor, fibroblast growth factor 2 | |
| Stimulate recruitment of endogenous progenitor cells |
