FIG. 6.

Associations between baseline percentages of IFN-γ⁺ cells and changes (n-fold) in the percentages after influenza vaccination. All subjects with data available for day 0 (baseline) and day 10 were included. (A) Scatter plots for the change (n-fold) in IFN-γ⁺ CD4 T cells versus baseline percentages of IFN-γ⁺ cells in CD4 and CD8 T-cell subsets and CD56^bright and CD56^dim NK cell subsets in adult and child (5- to 9-year-old) groups receiving LAIV or TIV. For reference, the dotted lines indicate a change (n-fold) of 1. (B) Complete list of estimated Spearman correlation coefficients, r_S, for change (n-fold) versus the baseline level of IFN-γ⁺ cells in all lymphocyte subsets. The criteria for statistical significance were adjusted across four cell subsets within each vaccine/age group to control the type I error rate at 5% across the 16 multiple comparisons. **, result that remained statistically significant after the adjustment; *, result with a P value of <0.05 in an individual test but that became nonsignificant after the adjustment. The average r_S was calculated across the change for four lymphocyte subsets versus the baseline percentage of each cell type in each age/vaccine group. FC, change (n-fold).