TABLE 3.
AAV2-AAV4 variable regions and reported functional roles in AAV2
| Variable region (amino acid residues)a | Functional role(s) in AAV2b | Reference(s) |
|---|---|---|
| I (262-268)a | Transduction, A20 and IVIG neutralization | 44, 67, 69 |
| II (326-330) | Transduction | 44 |
| III (380-388) | Transduction and A20 neutralization | 44, 67, 69 |
| IV (449-468) | HS and IVIG neutralization | 44, 69 |
| V (487-504) | Transduction, HB, HS and IVIG neutralization | 35, 44, 52, 69 |
| VI (525-541) | Transduction, HS and IVIG neutralization | 35, 44, 52, 69 |
| VII (544-556) | A20, HS, and IVIG neutralization | 44 |
| VIII (579-594) | HB, HS, and IVIG neutralization | 35, 44, 52 |
| IX (704-711) | Transduction, HB, A20, HS, and IVIG neutralization | 44, 67, 69 |
a
AAV2 VP1 numbering.
b
A20, AAV2 capsid antibody; IVIG, intravenous immunoglobulin G; HB, heparin binding; HS, human serum.