Table 1.
Characteristics of the hypothalamic NPY system in some genetic animal models. (ARC, arcuate nucleus; PVN, paraventricular rat; OLETF rat, Otsuka–Long–Evans–Tokushima Fatty rat; CPE, carboxypeptidase E; n.d., not described to our knowledge.)
| model | food intake | ARC content | ARC mRNA expression | Y1/Y5 receptors | PVN release |
|---|---|---|---|---|---|
| mutation at: | |||||
| leptin receptor gene | |||||
| Zucker fa/fa rat | ↑++ | ↑+++ | ↑+++ | Y1:↓/Y5:↓+ | ↑++ |
| db/db mouse | ↑++ | ↑++ | ↑+++ | n.d. | n.d. |
| cp/cp JCR : LA rat | ↑++ | ↑++ | ↑++ | n.d. | n.d. |
| Koletsky rat | ↑++ | ↑++ | ↑++ | n.d. | n.d. |
| leptin gene | |||||
| ob/ob mouse | ↑++ | ↑ or → | ↑+++ | Y5:↓+ | n.d. |
| CCK-A receptor | |||||
| OLETF rat | ↑++ | n.d. | ↓ | n.d. | n.d. |
| agouti gene | |||||
| yellow Ay mouse | ↑ | n.d. | → | n.d. | n.d. |
| tub gene | |||||
| tubby mouse | ↓ | n.d. | ↓ | n.d. | n.d. |
| CPE gene | |||||
| fat mouse | ↑late | n.d | n.d | n.d | n.d |