Figure 2.

Appetite suppressing effects of leptin. The figure illustrates the powerful inhibitory effect of leptin on food intake in ob/ob mice, which lack the functional hormone. Mice were injected with vehicle from days −4 to 0 and then with recombinant leptin (1.25 μg g⁻¹ body wt, twice daily) from days 0 to 7; they were then returned to vehicle injections. Adapted from Mercer et al. (1997).