Figure 5.
The antitumor effects of IFN-α are not enhanced after reconstitution of STAT1 signaling within the melanoma cell. (a) IFN-α treatment (open triangles) significantly (P < 0.01) prolonged the survival of C57BL/6 mice (n = 6 mice per group) bearing AGS-1 cells infected with empty vector (AGS-1MSCV) as compared with PBS-treated mice (filled circles). (b) IFN-α treatment (open triangles) also significantly (P < 0.01) prolonged the survival of C57BL/6 mice (n = 6 mice per group) challenged with the STAT1-reconstituted AGS-1 melanoma cell line (AGS-1STAT1) as compared with PBS-treated mice (filled circles). These results are representative of two separate determinations.