Figure 3.

Prophylactic and therapeutic treatment with M5 Ab ameliorated symptoms of arthritis. M5 Ab was administered intravenously at doses of 40, 150, and 400 μg per mouse before the onset of clinical symptoms on days 0 and 3. The arthritic group was intravenously administered 400 μg of rabbit IgG. Arthritic score (a), incidence of arthritis (b), food intake (d), and body weight (e) were monitored. Representative gross appearances of the forepaw are shown (c). Arthritic mice were therapeutically treated with M5 Ab after the onset of symptoms on day 3, and arthritic scores were monitored (f). Each point represents the mean score ± SEM of five mice. *P < 0.05 and **P < 0.01 for comparison by Mann-Whitney U test with arthritic mice; ^##P < 0.01 for comparison by Dunnet’s multiple-comparison test with arthritic mice.