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. 2003 May 12;100(11):6404–6409. doi: 10.1073/pnas.1131007100

Fig. 1.

Fig. 1.

Sequence identity among FNG proteins. The predicted amino acid sequences of four insect FNG proteins [Drosophila melanogaster (D.m.), P. coenia (P.c.), Schistocerca gregaria (S.g.), and Anopheles gambiae (A.g.)], aligned by the pile up program of GCG 10. Nonconserved amino- and carboxyl-terminal regions are not shown. This sequence corresponds to amino acids 149–410 of Drosophila FNG. Black boxes identify amino acids identical among all cloned FNG proteins, including 14 vertebrate FNG proteins. An alignment including these vertebrate genes is presented in Fig. 5. Gray boxes identify amino acids identical among all insect FNGs, but not all vertebrate FNGs. Lines above the sequence letters demarcate the conserved sequence motifs identified in Fig. 2. Letters above the sequence letters identify the locations of missense mutations in Drosophila FNG, and asterisks (*) above the sequence letters identify the locations of nonsense mutations (see Table 1).