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. 2003 May 12;100(11):6416–6421. doi: 10.1073/pnas.1130145100

Fig. 1.

Fig. 1.

Design of linear and circular 10–23 deoxyribozymes. (a) Active linear deoxyribozymes LA and LB and inactive circular deoxyribozymes CA and CB. The 10–23 catalytic core is shown in gray with substrate-binding arms shown in blac.k Complementary arms are denoted by upper and lowercase letters. The cleavage site, consisting of two ribose residues, is shown in outline. (b) Schematic for the autocatalytic 10–23 deoxyribozyme cleavase cycle. Cleavage of inactive CB by active LA produces active LB, which can in turn cleave inactive CA to reproduce active LA.