Skip to main content
. 2003 May 6;100(11):6505–6510. doi: 10.1073/pnas.1031790100

Fig. 5.

Fig. 5.

Inhibition of EGFR by AG1478 reduces its internalization. (A) The percentage EGFR internalization was measured in CHO cells, transfected with EGFR, and treated with AG1478, using radiolabeled EGF. Treatment with 5–10 nM AG1478 results in a decline in the amount of EGFR internalization. (B) The relative remaining EGFR on the surface of CHO cells, transfected with EGFR and treated with the indicated concentration of AG1478, was measured after exposure to EGF for the times indicated, using radiolabeled EGF. The values are expressed as a percentage of control cells that were not exposed to EGF. Treatment with AG1478 inhibited the decline in EGFR that was present at the cell surface over time.