Table 2. CP-533,536 induced changes in total bone area (TBA), total bone mineral content (BMC), and total bone mineral density (BMD) in the rat local injection model.

	CP-533,536, mg/kg
Measurements, % changes from vehicle	0.3	1.0	3.0
TBA	-4.7	4.4	20.6*
BMC	2.5	26.3*	53.5*
BMD	7.5*	20.7*	27.5*

^*P < 0.001 vs. vehicle.