Table 3.
Radiographic healing of ulnar critical defect in dogs treated with CP-533,536 at 24 weeks
Treatment groups
| Control, 1.0 ml of PLGH
|
50 mg of CP-533,536 + 1.0 ml of PLGH
|
10 mg of CP-533,536 + 1.0 ml of PLGH
|
10 mg of CP-533,536 + 0.2 ml of PLGH
|
||||
|---|---|---|---|---|---|---|---|
| Animal | Radiographic healing | Animal | Radiographic healing | Animal | Radiographic healing | Animal | Radiographic healing |
| 1 | 0 | 9 | 6 | 13 | 6 | 25 | 3 |
| 2 | 0 | 10 | 6 | 14 | 2 | 26 | 6 |
| 3 | 0 | 11 | 2 | 15 | 3 | 27 | 6 |
| 4 | 0 | 12 | 5 | 16 | 6 | 28 | 6 |
| 5 | 0 | 17 | 6 | ||||
| 6 | 0 | 18 | 6 | ||||
| 7 | 0 | 19 | 6 | ||||
| 8 | 0 | 20 | 4 | ||||
| 21 | 6 | ||||||
| 22 | 6 | ||||||
| 23 | 6 | ||||||
| 24 | 6 | ||||||
Radiographic grading scores (0-6) were as follows: 0, no change from immediate postoperative appearance; 1, trace of radiodense material in defects; 2, flocculent radiodensity with flecks of calcification and no defect bridging; 3, defect bridged at least one point with material of nonuniform radiodensity; 4, defect bridged in medial, and lateral sides with material of uniform radiodensity, cut ends of cortex remain visible; 5, same as grade 3, at least one of four cortices obscured by new bone; 6, defect bridged by uniform new bone, cut ends of cortex not seen (24).