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(A) Biweekly i.v. injections of asialoEPO over a wide dosage range do not change hemoglobin concentration in mice (n = 8 for each group; 50 μg/kg of bw and 200 μg/kg of bw omitted for clarity). (B) Biweekly i.p. administration of asialoEPO at a neuroprotective dose (100 μg/kg of bw) does not change the hemoglobin concentration. In contrast, an equal dose of rhEPO raises the hemoglobin concentration.
