Fig. 1.

Anti-E1/E2 titers in HCV-LP- or DNA-immunized AAD mice. The AAD mice were immunized, and the serum was harvested and assayed 2 wk after the last immunization for anti-E1/E2 as described in Materials and Methods. The anti-E1/E2 titer by endpoint dilution in ELISA of each mouse is shown. Mean values are expressed as geometric mean titers ± SEM and shown as bars on the left. Sera tested negative by ELISA were assigned an arbitrary titer of one-half of the initial dilution of 100. The P value is shown above. These data are representative of three similar experiments.