Table 2. PERV-A tropism and receptor utilization: receptor specificity.
| Approximate LacZ pseudotype titre, units/ml
|
||||
|---|---|---|---|---|
| Target cell line | PERV-A14/220 | PERV-A | PERV-B | PERV-C |
| SIRC (rabbit) | <4 | <4 | 49 | <4 |
| SIRC HuPAR-1 | 4 × 103 | 6 | 59 | <4 |
| SIRC HuPAR-2 | 2 × 104 | 1 × 103 | 36 | <4 |
| SIRC BaPAR-2 | 6 × 103 | NT | NT | NT |
| SIRC PoPAR | 1 × 103 | 2 × 104 | 29 | <4 |
| SIRC AK008081 | <4 | <4 | NT | NT |
| NIH3T3 (mouse) | <4 | <4 | NT | NT |
| NIH3T3 HuPAR-1 | 8 × 103 | 16 | NT | NT |
| ST-IOWA (pig) | 8 × 104 | 1 × 104 | 19 | 1 × 103 |
| 293 (human) | 8 × 104 | 1 × 104 | 127 | <4 |
| HT1080 (human) | 4 × 104 | 20 | NT | NT |
| HOS (human) | 2 × 103 | <4 | NT | NT |
HuPAR-1, HuPAR-2, BaPAR-2, and PoPAR are functional PERV-A receptors when expressed in SIRC and, for HuPAR-1, in NIH3T3 cells. NT, not tested.