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. 2003 May 14;100(11):6777–6782. doi: 10.1073/pnas.1131928100

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Fig. 3. — MBD1^-/- ANCs have higher expression of IAP and increased aneuploidy. (a) Real-time PCR shows significantly increased expression of IAP in MBD1^-/- ANCs (P = 0.038). (b) Western blot showing increased IAP GAG protein expression in MBD1^-/- ANCs. The levels of IAP GAG increased after treatment by TSA. (c and d) Distribution of WT (c) and MBD1^-/- (d) ANCs with different chromosome numbers. Arrows point to the number of cells with normal chromosome count (40 chromosomes per cell in this case). Note that most WT aneuploid cells lost chromosomes (e), whereas most MBD1^-/- cells gained chromosomes (d). (e) Increased percentage of aneuploid cells in MBD1^-/- ANCs (P = 0.02). (f) Example of a MBD1^-/- cell analyzed by SKY. (43, XY, +2, +10, and +18). White arrowhead indicates a fragment from chromosome 2. *; t test, P < 0.05.