Table 1. Reduced adiposity and plasma leptin levels in mice lacking the DP-IV gene.

Diet type	Fat mass, g	% Fat content	Lean mass, g	Leptin, ng/ml
WT 10% FD	9.1 ± 0.9	26.6 ± 2.0	19.5 ± 0.5	33.9 ± 4.9
-/- 10% FD	9.3 ± 0.8	26.9 ± 1.8	19.6 ± 0.6	33.8 ± 4.1
WT 45% FD	15.2 ± 0.5*	36.5 ± 0.9*	21.1 ± 0.5	62.7 ± 3.3*
-/- 45% FD	11.6 ± 1.4**	30.7 ± 2.6**	20.1 ± 0.8	41.8 ± 6.5**

WT and DP-IV^-/- mice were fed with 10% or 45% FD for 20 weeks. Body composition was determined by NMR.

^*, P < 0.05, comparing WT mice on 10% vs. 45% FD.

^**, P < 0.05, comparing WT on 45% FD with DP-IV^-/- mice on same diet; n = 17.