Table 1. Inhibition by O-3 derivatives of d-glucose on hexose transport mediated by PfHT in oocytes and on cultured P. falciparum.

C3 analogue	KI for D-glucose uptake	KI for D-fructose uptake	IC50 (P. falciparum growth)
3-O-ethyl-D-glucose	1.62 ± 0.72	2.67 ± 0.66	3.70 ± 1.041
3-O-benzyl-D-glucose	2.19 ± 0.85	1.49 ± 0.93	5.23 ± 1.063
3-O-hydroxyethyl-D-glucose	14.8 ± 1.4	> 10	> 10
3-O-((undec-10-en)-1-yl)-D-glucose (compound 3361)	0.053 ± 0.019	0.027 ± 0.003	0.0157 ± 0.0017

Experiments were performed on strain 3D7 with 4 mM D-glucose. Values (mean ± SE of three independent replicates) are expressed in mM.