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Structural analysis of MIC genes. (A) Evolutionary time line for duplication of the ancestral MICA and MICB genes, insertion of AluY and AluS elements, and separation of the human and chimpanzee lineages. The time line (millions of years ago) is shown along the vertical axis. (B) Comparative genomic map of the exon, intron, and retroelement (Alu, L1, LTR, and MIR) organization of human MICA, MICB, and Patr-MIC genes.
