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(A) Vastus lateralis muscle mitochondrial ATP production rates after 7 h of high-dose insulin infusion. Values (mean ± SEM) are expressed as a percentage change from the low-dose insulin condition. Measurements were made in the presence of six different substrate combinations (KG, 10 mMα-ketoglutarate). (B) Insulin concentrations sustained during 7 h of insulin infusion (mean ± SD). *, Significant difference between the low-dose and high-dose insulin conditions (P < 0.02).
