FIG. 3.

Measles virus V protein STAT3 interference inhibits IL-6 and v-Src transcriptional responses. (A) Measles virus V inhibits IL-6 signaling. GAS-luciferase reporter gene assays were carried out with 2fTGH cells as in Fig. 1, but the cells were transfected with empty vector or measles virus V expression vector as indicated and then treated with IL-6 (400 ng/ml) plus soluble IL-6 receptor (500 ng/ml) or left untreated, as described previously (14, 57). (B) Measles virus V inhibits v-Src signaling. The GAS-luciferase assay was carried out as in panel A, but with cotransfected v-Src expression vector as the STAT3 activator.