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Structure of Vps4. The modeled structure of the Vps4 AAA domain hexamer was modeled (93) is shown together with the corresponding six copies of the MIT domain (94). For simplicity, a single subunit of the ESCRT-III complex is shown engaged to a single MIT domain. The ESCRT-III subunit is thought to be fed through the central pore in the hexamer (not shown in this view) as ATP is hydrolyzed by the AAA domain.
